Chromosomal Instability Essay Example | Topics and Well Written Essays - 2250 words

Chromosomal Instability - Essay Example due to the aberrations in the genomes, there is chromosomal instability leading to aneuploidy, i.e, an imbalance in the chromosomes results, so that the possibility for cancerous growths is increased.(Pollack, 2006). In a brief article, Pollack (2006) has summarized the findings of a study of aneuploidy that was taken up recently, where a gene expression was identified as a possible identifying symptom of chromosomal instability. In their study of chromosomal instability, the authors identified 25 genes that could predict the clinical outcome for six different types of cancer. Maintaining the chromosomal integrity of a cell is a complicated process because DNA regulation in the cell must be precisely regulated, while damaged DNA must be recognized and repaired quickly. Shima et al (2007) conducted earlier studies where they identified a Chaos3 mutation in mice that causes spontaneous chromosomal aberrations. In the instant study, they report that this chromosomal instability, which was isolated in a forward genetic screen, is a viable allele of Mcm4 (michromosome maintenance deficient 4 homolog). This allele is a component of the MCM2-7 complex, which is the replication licensing factor. Shima et al (2007) conducted their study on female mice and found that mutant embryonic fibroblasts in these mice were susceptible to chromosomal instability induced by inhibition of DNA replication. 80% of the subjects of the study succumbed to mammary carcinomas. The findings in this study suggest that the hyphomorphic alleles such as mcm4 of the genes that encode the subunits of the MCM2-7 complex may cause an increase in the risk of breast cancer. Another causal element identified in chromosomal instability is the mSds3 chromatin regulator, which is a key component of the mSin3 compressor complex that regulates target gene expression through chromatin modification.(David et al, 2006). In their study, David et al (2006) carried out their study using mice assessed whether the